Wnt Signaling Pathway Inhibitors therapeutics currently exhibits a proliferating pipeline with 27 therapeutic candidates.
Wnt signaling pathway plays an important role in embryonic development. The signaling pathway regulates cell-to-cell interaction, accelerates trophoblast development, activates blastocyst, accelerate chorion-allantois fusion and implantation. A wide range of diseases, such as different types of cancer and degenerative diseases can be treated by deregulation of components involved in Wnt/β-catenin signaling pathway. Also, researchers have demonstrated that moderate weakening of Wnt signaling can eliminate its carcinogenic potential. Based on the recent researches, Wnt Signaling Pathway inhibitors have also shown potential in cardiovascular disorders.
It has been observed that many pharmaceutical companies are leveraging new and improved technologies for the development of Wnt Signaling Pathway inhibitors. These technologies play an important role in the drug development thereby helping the companies develop more specific and effective targeted therapies. For instance, the focus of Samumed's technology platform is on the ability to modulate the Wnt signaling pathway in selected tissues with small molecules. The company has discovered various new biological processes related to the Wnt signaling pathway, identified novel biological targets, and developed small-molecule drugs that modulate Wnt activity. In addition, JW Pharmaceutical CORPORATION is engaged in the development of novel therapeutics using high-throughput screening technology and chemical library. The company specializes in identifying small molecule drugs that modulate signaling pathways involved in cell proliferation and differentiation.
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Some of the key players involved in the development of Wnt signaling pathway inhibitors in the late and mid stage include Samumed LLC, Can-Fite BioPharma Ltd., Tactical Therapeutics Inc., Leap Therapeutics Inc., 2X Oncology Inc., Eisai Co. Ltd., and Novartis AG.
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